Naltrexone has been used in lower doses to treat multiple diseases since 1988. Naltrexone is considered “standard dose” when given in daily amounts of 25mg or more and low dose when the daily dose is less than or equal to 4.5mg. When prescribed in standard dose, Naltrexone acts primarily to block opiate receptors and as such is used mainly in addictions. When used in low dose, it is now widely understood to act as an Immunomodulator, opiate blocking and anti-tumor effect.
Low-Dose Naltrexone (LDN) Improves Immune System Responses (Helps with automimmune diseases)
• LDN creates an increase in the production of endorphins, which should result in a reduction of painful symptoms and an increased sense of wellbeing
• LDN increases levels of endorphins should be expected to stimulate the immune system, promoting an increase in the number of T lymphocytes. This effect was first documented by Dr. Bihari in New York. This increase in T-cell numbers apparently restores a more normal balance of the T-cells. The effects of the disease process are significantly reduced.
• LDN may also act directly on these immune cells to stimulate or restore normal immune functions.
Opiate Blockade 4-6 hours (Helps to decrease pain)
• Levo Naltrexone molecule binds to opiate receptors
• Causes a rebound-increase of endorphin release.
• Increases sensitivity of existing opiate/ endorphin receptors.
• More opiate receptors are formed to capture endorphins, after LDN treatment.
Cancer (Helps to treat cancer)
• Intermittent Dosing with LDN causes increased cell death in certain cancers, and increases cell sensitivity to chemotherapy agents.
• Certain cell types treated with LDN up regulate genes that are responsible for cell death. (BAD and BIK1)
• Certain Tumor Cells pre-treated with intermittent LDN dosing are far more likely to be killed by chemotherapy drugs.
• LDN seems to have a direct cytotoxic effect on cancer cells, via a P13 kinase, cyclin P21 and downstream G-Protein coupled receptor routes.
Which diseases are being treated with LDN?
Inflammatory Bowel Disease (Crohn's/Ulcerative Colitis)
Complex Regional Pain Syndrome (CRPS)
Diabetes Type I
Anxiety and Depression
Esophageal and Oral Cancers
Non-Small Cell Cancer
Renal Cell Cancer
Duodenal and Stomach Cancer
Possible Side Effects
LDN is well tolerated but some common side effects are sleep disturbances, mild headache, mild agitation, and nausea.
The cost is $250 for the initial visit and then $150 for follow-up visits every two months. This does not include the cost of the medication. Included with each visit is a vitamin B12 injection.
Low Dose Natrexone http://www.lowdosenaltrexone.org/ldn_trials.htm
How LDN Works http://www.ldnresearchtrust.org/how-naltrexone-works
Conditions That LDN Could Help http://www.ldnresearchtrust.org/conditions#Malignancies/cancers
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